Rabenosyn-5, Rabaptin-5, Rab-7, VPS45A, 22.214.171.124, 1-(1,2-diacyl-glycerol 3-phospho)-inositol 3-phosphate, PI3K cat class III, CFTR, PI3K reg class III, RABGEF1, VAMP2, Rab-5A, Syntaxin 12, CFTR, 1,2-diacyl-glycerol 3-phosphoinositol, Ubiquitin, EEA1, SNAP-25, NSF
Normal wtCFTR traffic/ Sorting endosome formation
The cystic fibrosis transmembrane conductance regulator ( CFTR ) is a member of the ATP-binding cassette transporter superfamily. It acts in apical part of the epithelial cells as a plasma-membrane cyclic AMP-activated chloride anion, bicarbonate anion and glutathione channel , , . Cell surface expression of the CFTR is a highly regulated intracellular process , .
CFTR internalization from plasma membrane is a very important step in CFTR regulation. CFTR may be internalizated from plasma membrane in a clathrin-dependent manner. Then the coated-pit-derived primary endocytic vesicles are fused with the sorting endosomes. The fusion event is regulated by a member of RAS oncogene family Rab-5A, Early endosome antigen 1 ( EEA1 ) ,  and Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) , .
Some wtCFTR is transported from the sorting endosome to the lysosome in Ub-dependent manner and is degraded .