Pathway Map Details
Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
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Cholesterol and Sphingolipid transport/ Influx to the early endosome in lung (normal and CF)
Lung cells absorb Cholesterol preferentially as Cholesteryl ester bound to lipoprotein particles such as Intermediate density lipoproteins ( IDL ) and Low density lipoproteins ( LDL ) . These lipoproteins are recognized by corresponding low density lipoprotein receptor ( LDLR ) , , , . LDLR is internalized into clathrin-coated pits and transported to sorting endosomes. Disabled homolog 2 ( Dab2 ) protein mediates internalization of Low density lipoprotein receptor ( LDLR ) independently of LDL receptor adaptor protein 1 ( ARH ) and the Adaptor-related protein complex 2 ( AP-2 ). If Dab2 is absent, ARH can mediate LDLR endocytosis. This mediation requires AP complex 2 , .
Sphingolipid -containing membranes are internalized via the caveolae-raft or clathrin-dependent pathways that involve Caveolin-1 .
Further lipid sorting from early endosomes to sorting endosomes is mediated by members of the RAS oncogene family Rab-5A and Rab-4 in clathrin vesicles formed from pits. Rab-5 -independent sorting also occurs in caveolae endosomes .
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