Beta-1 adrenergic receptor, PKA-cat (cAMP-dependent), CFTR, ATF-1, Noradrenaline extracellular region, cAMP, 188.8.131.52, Adenylate cyclase, PKA-reg (cAMP-dependent), Beta-3 adrenergic receptor, ATP, Adrenaline extracellular region, G-protein alpha-s, Beta-2 adrenergic receptor, CREB1
Beta-adrenergic-dependent CFTR expression
Beta-adrenergic receptor modulates expression of the Cystic fibrosis transmembrane conductance regulator ( CFTR )  via elevation of Adenosine 3',5'-cyclic phosphate -( cAMP ) mediated by GNAS complex locus ( G - protein alpha-s )/ Adenylate cyclase/ cAMP. High cAMP concentration leads to activation of the PKA and, subsequently, of cAMP responsive element binding protein 1 ( CREB1 ) and transcription factor 1 ( ATF-1 )-dependent transcription of CFTR. cAMP-dependent activation of CFTR transcription is still being studied and appears to be more complex than believed previously , , .